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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
23/01/2020 |
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Data da última atualização: |
20/04/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
DEFANT, H.; MEIRA, A. N.; COUTINHO, L. L.; REGITANO, L. C. de A.; POLETI, M. D.; MOREIRA, G. C. M.; PADUAN, M.; MARIANI, P.; ZERLOTINI NETO, A.; MOURÃO, G. B.; CESAR, A. S. M. |
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Afiliação: |
HELOISA DEFANT, Esalq/USP; ARIANA N. MEIRA, Esalq/USP; LUIZ L. COUTINHO, Esalq/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; MIRELE D. POLETI, USP; GABRIEL C. M. MOREIRA, Esalq/USP; MARCELA PADUAN, Esalq/USP; PILAR MARIANI, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; GERSON B. MOURÃO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP. |
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Título: |
Novel polymorphisms in the PLIN2 gene of Nellore cattle. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Genetics and Molecular Research, v. 18, n. 3, 2019. |
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Páginas: |
Não paginado. |
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Idioma: |
Inglês |
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Notas: |
Na publicação: Luciana CA Regitano, Adhemar Zerlotini. gmr16039963. |
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Conteúdo: |
ABSTRACT. Genetic variations in genes involved in lipid storage, which also may interfere with important phenotypic traits such as intramuscular fat deposition in cattle, can represent useful markers in marker assisted selection programs. An important candidate gene is perilipin 2 (PLIN2) that plays a role in the capture of long chain fatty acids and in the formation and stabilization of lipid droplets in different tissues including muscle. As reported by our group, PLIN2 expression level was associated with trans-eQTL (expression quantitative loci distant of gene associated) at chr3: 87, 253, 086 in Nellore cattle, where animals with different genotypes showed different expression level of PLIN2 among the 193 animals and the co-expression analysis detected correlation with intramuscular fat, palmitoleic, oleic and linoleic acids. Then, the objective of this study was to identify and characterize polymorphisms present in the PLIN2 gene of Nellore cattle. To date, there is not much information on mutations in the PLIN2 gene in Bos indicus animals. A total of 134 single nucleotide polymorphisms (SNPs) were identified in the genomic region of PLIN2 gene and five of those are novel with a moderate impact. These SNPs may change the protein effectiveness and, after further association studies and functional validation, could be used as genomic markers in animal breeding program. |
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Palavras-Chave: |
Biological process; Expressão gênica; Gordura intramuscular; Gota lipídica; Lipid droplet; Perilipin 2; PLIN2; Polimorfismo de nucleotídeo único; Processos biológicos; SNP; Variants. |
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Thesagro: |
Bos Indicus; Gado. |
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Thesaurus Nal: |
Cattle; Gene expression; Intramuscular fat; Nellore; Single nucleotide polymorphism. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/209752/1/NovelPolymorphismsPLIN2.pdf
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Marc: |
LEADER 02742naa a2200481 a 4500
001 2119464
005 2020-04-20
008 2019 bl uuuu u00u1 u #d
100 1 $aDEFANT, H.
245 $aNovel polymorphisms in the PLIN2 gene of Nellore cattle.$h[electronic resource]
260 $c2019
300 $aNão paginado.
500 $aNa publicação: Luciana CA Regitano, Adhemar Zerlotini. gmr16039963.
520 $aABSTRACT. Genetic variations in genes involved in lipid storage, which also may interfere with important phenotypic traits such as intramuscular fat deposition in cattle, can represent useful markers in marker assisted selection programs. An important candidate gene is perilipin 2 (PLIN2) that plays a role in the capture of long chain fatty acids and in the formation and stabilization of lipid droplets in different tissues including muscle. As reported by our group, PLIN2 expression level was associated with trans-eQTL (expression quantitative loci distant of gene associated) at chr3: 87, 253, 086 in Nellore cattle, where animals with different genotypes showed different expression level of PLIN2 among the 193 animals and the co-expression analysis detected correlation with intramuscular fat, palmitoleic, oleic and linoleic acids. Then, the objective of this study was to identify and characterize polymorphisms present in the PLIN2 gene of Nellore cattle. To date, there is not much information on mutations in the PLIN2 gene in Bos indicus animals. A total of 134 single nucleotide polymorphisms (SNPs) were identified in the genomic region of PLIN2 gene and five of those are novel with a moderate impact. These SNPs may change the protein effectiveness and, after further association studies and functional validation, could be used as genomic markers in animal breeding program.
650 $aCattle
650 $aGene expression
650 $aIntramuscular fat
650 $aNellore
650 $aSingle nucleotide polymorphism
650 $aBos Indicus
650 $aGado
653 $aBiological process
653 $aExpressão gênica
653 $aGordura intramuscular
653 $aGota lipídica
653 $aLipid droplet
653 $aPerilipin 2
653 $aPLIN2
653 $aPolimorfismo de nucleotídeo único
653 $aProcessos biológicos
653 $aSNP
653 $aVariants
700 1 $aMEIRA, A. N.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
700 1 $aPOLETI, M. D.
700 1 $aMOREIRA, G. C. M.
700 1 $aPADUAN, M.
700 1 $aMARIANI, P.
700 1 $aZERLOTINI NETO, A.
700 1 $aMOURÃO, G. B.
700 1 $aCESAR, A. S. M.
773 $tGenetics and Molecular Research$gv. 18, n. 3, 2019.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Biblioteca |
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| Registros recuperados : 9 | |
| 1. |  | AYALA, L. M.; EUPEN, M. van; PÉREZ-SOBA, M.; ZHANG, G.; MARTORANO, L. G.; LISBOA, L. S.; BELTRÃO, N. E. Impact of soybean expansion on Water Footprint in the Amazon under climate change scenarios. In: WORLD WATER CONGRESS, 15., 2015, Edinburgh. [Posters]. [S.l.]: IWRA, 2015.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
|    |
| 2. | | AYALA, L. M.; EUPEN, M. van; ZHANG, G.; PÉREZ-SOBA, M.; MARTORANO, L. G.; LISBOA, L. S.; BELTRÃO, N. E. Impact of agricultural expansion on water footprint in the Amazon under climate change scenarios. Science of the Total Environment, v. 569/570, p. 1159-1173, Nov. 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Amazônia Oriental. |
|  |
| 3. | | TURETTA, A. P. D.; FONTE, G.; ORTIZ VALENCIA, L. I.; EUPEN, M. van; PEREZ-SOBA, M.; COUTINHO, H. L. da C.; OYARZABA, M.; BAEZA, S.; SIMÕES, M.; FISTAROL, G.; SCHLINDWEIN, S. Adaptation and preparation of a Spatial Regional Reference Framework for MERCOSUR regions. Rio de Janeiro: Embrapa Solos, 2009. 223 p.| Tipo: Monitoramento/Zoneamento |
| Biblioteca(s): Embrapa Solos. |
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| 4. | | PÉREZ-SOBA, M.; PARR, T.; WINOGARD, M.; CLAROS, M. P.; VARELA-ORTEGA, C.; ASCARRUNZ, N.; BALVANERA, P.; BHOLANATH, P.; EQUIHUA, M.; MARTORANO, L. G.; JONES, L.; MAASS, M.; THONICKE, K. Framework for multi-scale integrated impact analyses of climate change mitigation options. In: INTERNATIONAL CONFERENCE ON CLIMATE CHANGE EFECTS, 2013, Potsdam. Impacts world 2013. [Potsdam: Potsdam Institute for Climate Impact Research], 2013.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 5. | | COUTINHO, H. L. da C.; TURETTA, A. P. D.; MARTORANO, L. G.; MONTEIRO, J. M. G.; SCHULER, A. E.; MEIRELLES, M. S. P.; SIEBER, S.; VERWEIJ, P.; PEREZ-SOBA, M.; TSCHERNING, K.; HELMING, K. Sustainability Impact Assessment Tools to support the development of policies leading to land use change processes: the Sensor Project approach applied to sugarcane expansion in Brazil. In: GLP OPEN SCIENCE MEETING, 2010, Tempe, AZ. Anais... Tempe, AZ: [ESSP], 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos. |
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| 6. | | COUTINHO, H. L. C.; TURETTA, A. P. D.; MARTORANO, L. G.; MONTEIRO, J.; SCHULER, A.; MEIRELLES, M. S. P.; SIEBER, S.; VERWEIJ, P.; PEREZ-SOBA, M.; TSCHERNING, K.; HELMING, K. Sustainability Impact Assessment Tools to support the development of policies leading to land use change processes: the Sensor Project approach applied to sugarcane expansion in Brazil. In: GLP OPEN SCIENCE MEETING, 2010, Tempe, AZ. Anais... Tempe, AZ: [ESSP], 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
| |
| 7. | | BALVANERA, P.; JONES, L.; SIMÕES, M.; QUIJAS, S.; MASANTE, D.; EQUIHUA, M.; VARELA, C.; LAZOS, E.; PÉREZ-MAQUEO, O.; EQUIHUA, J.; KOLB, M.; ALANIS, N. G.; THONICKE, K.; PURSE, B.; MARTORANO, L.; AZCARRUNZ, N.; BELTRAO, N.; MAASS, M.; GERRITSEN, P.; VERBOOM, J.; BLANCO, I.; BOIT, A.; DAY, J.; DÍAZ, J.; DÍAS, P.; ESTEVE, P.; FERRAZ, R.; IBAÑEZ-BERNAL, S.; JARAMILLO, V.; MURRAY-TORTAROLO, G.; PÉREZ-SOBA, M.; BRAAT, L.; MWAMPAMBA, T.; NASCIMIENTO, N.; PEÑA-CLAROS, M.; PEREIRA, S.; POORTER, L.; SCHMIDT, M.; SKUTSCH, M.; SMITH, R.; THOMPSON, J.; TOLEDO, M.; EUPEN, M. van. Present and future tradeoffs between biodiversity, ecosystem services and human well-being in tropical Latin America. In: INTERNATIONAL ECOSYSTEM SERVICES PARTNERSHIP CONFERENCE, 8., 2015, Stellenbosch. Ecosystem services for nature, people, and prosperity: book abstract. [S.l.: s.n.], 2015. p. 367-368.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos. |
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| 8. | | BALVANERA, P.; JONES, L.; SIMOES, M.; QUIJS, S.; MASANTE, D.; EQUIHUA, M.; VARELA, C.; LAZOS, E.; PÉREZ-MAQUEO, O.; EQUIHUA, J.; KOLB, M.; ALANIS, N. G.; THONICKE, K.; PURSE, B.; MARTORANO, L.; AZCARRUNZ, N.; BELTRAO, N.; MAASS, M.; GERRITSEN, P.; VERBOOM, J.; BLANCO, I.; BOIT, A.; DAY, J.; DÍAZ, J.; DÍAS, P.; ESTEVE, P.; FERRAZ, R.; IBAÑEZ-BERNAL, S.; JARAMILLO, V.; MURRAY-TORTAROLO, G.; PÉREZ-SOBA, M.; BRAAT, L.; MWAMPAMBA, T.; NASCIMIENTO, N.; PEÑA-CLAROS, M.; PEREIRA, S.; POORTER, L.; SCHMIDT, M.; SKUTSCH, M.; SMITH, R.; THOMPSON, J.; TOLEDO, M.; EUPEN, M. van. Present and future tradeoffs between biodiversity, ecosystem services and human well-being in tropical Latin America. In: INTERNATIONAL ECOSYSTEM SERVICES PARTNERSHIP CONFERENCE, 8., 2015, Stellenbosch. Ecosystem Services for Nature, People, and Prosperity: book abstract. [S.l.: s.n.], 2015. p. 367-368.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
| |
| 9. | | MARTORANO, L. G.; TAVARES, H.; SCHULER, A. E.; MEIRELLES, M. S. P.; VALENCIA, L. I. O.; SANTOS, F. L. de O.; LISBOA, L.; TEIXEIRA, F. A.; PEREIRA, S.; FERRAZ, R. P. D.; MONTEIRO, J. M. G.; TURETTA, A. P. D.; COUTINHO, H. L. da C.; SIEBER, S.; MÜLLER, K.; POHLER, D.; TSCHERNING, K.; HELMING, K.; FISTAROL, G.; SCHLINDWEIN, S.; FANTINI, A. C.; MARTINS, S. R.; D' AGOSTINI, L. R.; OYARZABAL, M.; PEÑA, E. V. V.; PIÑERO, G.; JOBBAGY, E.; PARUELO, J.; ALTESOR, A.; BAEZA, S.; VERWEIJ, P.; EUPEN, M. van; PÉREZ-SOBA, M.; VERBURG, P. H. SIAT-TTC design and architecture, sustainability impact assessment tool prototype: demonstration tool at TTC-level, for MERCOSUR. [Rio de Janeiro: Embrapa Solos], 2007. 126 p.| Tipo: Metodologia Cientifica |
| Biblioteca(s): Embrapa Solos. |
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| Registros recuperados : 9 | |
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